Liver impairment may be hereditary or due to certain long-term illnesses, overuse of certain medications
and/or heavy alcohol use. Aside from the fact that our medical and research professionals are dedicated
to consistently discovering innovations for the diagnosis, prevention and treatment of medical
conditions, illnesses and diseases, Riverside Clinical Research is immersed in research associated with
liver damage largely due to the fact that the liver is critical to the performance of so many vital body
For instance, an impaired liver may be deficit in protein production. Limited protein production can
result in the body’s diminished ability to properly clot blood, so profuse bleeding can occur from even
very small injuries. Severe bruising may be caused from very little trauma as well since a damaged liver
is often the cause of blood disorders that may result in easy bruising.
Fatigue is also a very common symptom of liver impairment; and in severe cases of liver disease,
confusion, muscle weakness and even coma may occur. Many researchers hypothesize that chronic
fatigue could be due to the alterations in certain hormones and brain chemistry caused by liver deficits,
but this theory has yet to be proven.
Other effects of liver impairment that may affect daily life include swollen legs, ankles and feet. Swollen
legs, ankles and feet may occur when a damaged liver begins to poorly circulate proteins or not circulate
proteins at all. These poorly or uncirculated liquids then gravitate to the lower extremities. Kidney
impairment due to a weakened liver may also lead to similar swelling in the lower extremities.
Liver impairment may also cause swelling in the abdominal area, as fluid can enter the abdominal cavity
when the liver is weakened. This fluid build-up within the abdominal cavity may result in pain within the
upper right abdomen and, in some cases, back and shoulder pain. The severity of this pain can widely
vary from patient to patient. Shortness of breath may be another symptom of abdominal swelling due to
The liver is also responsible for the body’s bile production and secretion. As bile cannot be adequately
secreted and it builds up within the blood, jaundice may occur. Jaundice can turn the whites of the eyes
yellow. The intensity to which jaundice turns the whites of the eyes yellow will have a direct correlation
to how much bile is trapped within the body. Severe cases of jaundice may negatively affect brain
Liver damage may also change urine to a darker color and stools to a pale, chalky color. If stools take on
a tar-like consistency and color, it may indicate that blood is not properly circulating and it may even be
indicative of end-stage liver failure.
An impaired liver that fails to filter toxins from the lungs will cause bad breath. Daily life is also affected
when an impaired liver becomes inflamed and loss of appetite, nausea and/or vomiting ensues.
Additionally, chronic liver disease increases estrogen which can cause spider veins.
Allergies can also be caused by an impaired liver. Once the liver weakens to the point where it cannot
properly excrete wastes, toxins will remain in the bloodstream, causing the immune system to
overreact, thereby causing allergic reactions.
The profound effect that liver impairment has on the brain may be one of the lesser known evils of liver
damage. While a normal functioning liver will work toward eliminating chemical byproducts such as
ammonia and manganese, a diseased liver may allow those harmful substances to build up in the blood
and flow through the brain.
Hepatic encephalopathy, otherwise referred to as brain disease, is brain damage which may be caused
by a failing liver. Sleep pattern alterations, along with depression and anxiety are common side effects
of brain disease caused by liver impairment, as are more serious symptoms such as behavioral changes,
confusion, poor judgement, slow speech, hindered movement as well as hand tremors. In worse case
scenarios, brain disease due to liver impairment may lead to coma or even death.
Another type of brain damage due to liver disease is Wernicke syndrome. Wernicke syndrome is a
condition in which liver damage causes low thiamine levels and the results can be mind-boggling.
Symptoms may manifest in varying degrees of coordination problems, decreased mobility, paralysis of
the eye muscles and confusion.
According to the National Institute of Health, Korsakoff’s psychosis starts where Wernicke syndrome
stops. Korsakoff’s psychosis affects up to 90 percent of people suffering from Wernicke syndrome and
can result in severe memory loss, coordination deficits and hallucinations. Heavy drinking is one of the
largest impediments of thiamine absorption. Consequently, approximately 80 percent of all alcoholics
develop a deficiency in thiamine, according to the National Institute of Alcohol Abuse and Alcoholism.
If you suffer from liver impairment and you are interested in participating in a clinical study, you can call
the professionals at Riverside Clinical Research at 386-428-7730 Monday through Thursday from 7 a.m.
to 5 p.m. or Friday from 7 a.m. to 12 p.m. to learn more; or email your questions to
email@example.com. You can also become more familiar with Riverside Clinical Research
and the clinical studies it conducts by accessing the Riverside Clinical Research patient portal at
An award-winning research facility that has earned a stellar reputation for clinical research trial
trendsetting, Riverside Clinical Research is considered one this area’s best medical research facilities.
Riverside Clinical Research can support up to 26 in-house patients and a large number of outpatients;
and its doctors and experienced research professionals work closely with clinical trial volunteers to
monitor and assess the benefits and effectiveness of certain treatment. Riverside Clinical Research is
conveniently located at 1410 S. Ridgewood Avenue in Edgewater, Florida.