If You Suffer from Heartburn, a Clinical Trial May Be a Good Option for You

Study Information

Do you suffer from symptomatic non-erosive gastroesophageal reflux disease (NERD)? If you think you do, you may qualify for participation in clinical research that could be beneficial to you. Velocity Clinical Research is now enrolling clinical trial volunteers for the purpose of researching and determining whether the investigation drug, vonoprazan, is safe and effective in the potential treatment of symptomatic NERD compared to a placebo.

Specifically, this Velocity Clinical Research heartburn study is a phase 3, randomized, double-blind study to evaluate the efficacy and safety of 10 and 20 mg dosages of vonoprazan as compared to a placebo for the relief of heartburn symptoms in patients with symptomatic NERD after 4 weeks and to evaluate the efficacy and safety vonoprazan 10 and 20 mg for relief of heartburn in subjects with NERD after 6 months.

To participate in this clinical study, you have to have experienced frequent heartburn over the last 6 months; you must be at least 18 years of age; and you will need the approval of a physician who is affiliated with this Velocity Clinical Research heartburn study to determine if you are fully eligible and if this study is right for you.

Should you decide that you would like to participate in this heartburn clinical research, your study physician will provide you with the study drug, which could contain either active treatment or a placebo. Then you will be asked to attend a total of 10 study visits, 6 of which will be in person at a study location and 4 phone call contacts – all of which will take place over the course of 33 weeks. These assessments are performed for the purpose of tracking your overall health and progress throughout the study.

How to Learn More or Begin this Clinical Study Volunteering Process 

Volunteering to help clinicians attain a greater understanding of certain conditions and develop new treatments for those conditions is a noble pursuit. If you have questions or think you would like to play an integral role in enhancing medical evaluation and care, as well as take advantage of the personal benefits of becoming a Velocity Clinical Research volunteer, call 386-428-7730 Monday through Thursday from 7 a.m. to 5 p.m. or Friday from 7 a.m. to 12 p.m for more information. Velocity Clinical Research volunteers are paid for their time, there are no costs for the medical procedures or treatments provided and there is no insurance necessary to participate.

About Velocity Clinical Research

The mission of Velocity Clinical Research is to make the world a better place, with a future filled with hope and incredible medical possibilities. Through vigilant monitoring and testing and with persistent dedication, the Velocity Clinical Research study team works tirelessly toward developing crucial interventions that could help both our clinical trial volunteers and the greater community as a whole.

The Velocity Clinical Research doctors and experienced research personnel work one-on-one with clinical trial volunteers to monitor and assess the benefits and effectiveness of certain treatments. Velocity Clinical Research can support up to 26 in-house patients and a large number of outpatients. The Velocity Clinical Research facility is conveniently located at 1410 S. Ridgewood Avenue in Edgewater, Florida.

Heartburn:  Symptoms, Causes, Diagnosis, Treatment and Potential Dangers

Heartburn can cause discomfort, and when it becomes persistent, it can interfere with your activities of daily living and may even be a sign of a potentially dangerous condition. When heartburn is accompanied by severe chest pain and/or pressure, difficulty breathing and/or swallowing, nausea and/or vomiting, it could mean you are experiencing a heart attack. In this instance you should seek immediate medical attention. Heartburn can also turn into gastroesophageal reflux disease (GERD) if it becomes chronic. GERD, which may require prescription medication, surgery or other procedural treatment, can create serious esophagus damage as well as lead to a precancerous condition called Barrett’s Syndrome. 

More typically, heartburn is a burning pain in the chest which can be accompanied by a sour taste in the mouth and slight regurgitation in the throat. Normally, when we swallow, the esophagus relaxes to allow for the intake of food and beverages and tightens once again afterward. If the esophageal muscles weaken or do not perform properly, stomach acid can flow back up into the esophagus, resulting in heartburn symptoms.

Certain causes of heartburn can include overeating, eating spicy foods such as pepperoni or onions, eating greasy or heavy, rich, fatty foods, eating acidic foods or beverages such as tomato sauce or orange juice, consuming alcohol or caffeinated drinks like coffee, tea or soda, or eating just before bed. Stress and certain medications and vitamins can exacerbate heartburn symptoms.

A doctor can help determine the severity of your heartburn. Imaging is typically used in the diagnosis of heartburn. Esophageal motility testing measures movement and pressure within the esophagus. An upper endoscopy, a procedure in which a flexible tube with a camera on the end is inserted down the throat, may also be used to gain a better visual. Ambulatory acid probe tests – which are the use of an acid monitor which is placed within the esophagus and connected to a small computer that is worn around the waist or strapped over the shoulder – are sometimes utilized to determine when and measure how long stomach acid backs up into the esophagus. A tissue sample may also be taken to check for any abnormalities.

Lifestyle changes can often help ease the symptoms of heartburn. These include maintaining a healthy weight; avoiding overeating and indulging in any foods or beverages which have more potential to cause heartburn; avoiding smoking, which can decrease the proper function of the lower esophageal sphincter; and waiting a few hours before lying down after eating. 

There are also over the counter medications which can be taken to alleviate the symptoms of heartburn, including antacids, which quickly neutralize stomach acids. H-2 receptor antagonists don’t work as quickly as antacids, but they may provide longer relief; and there are also proton pump inhibitors, such as Nexium and Prilosec, to reduce stomach acids. However, if any over the counter medications are used too often or for too long, they may begin to lose their effectiveness.